Your Partner for Preclinical and Translational Oncology Imaging
Perceptive Discovery delivers advanced preclinical oncology imaging and radiopharmaceutical development services to support therapeutic programs from discovery through early clinical development. Our cross-disciplinary team of radiochemists, imaging scientists, and oncology pharmacologists, work collaboratively to de-risk discovery and early-phase development by visualizing images of anti-tumor efficacy, target engagement, pharmacokinetics, dosimetry and therapeutic biodistribution in clinically relevant tumor models.
With deep expertise in radiopharmaceuticals and radioligand therapy (RLT), we help clients design and validate custom-labeled agents, quantify tumor uptake, and predict human dose and safety profiles—accelerating the path from concept to clinic.
A Proven Leader in Preclinical Oncology Imaging
- 11,000+ studies completed across imaging modalities
- Full suite of multi-modality imaging for oncology research: PET, SPECT, MRI, CT, bioluminescence (BLI), fluorescence (FLI), and cryofluorescence tomography (CFT)
- Specialized in radiopharmaceutical therapies, Antibody Drug Conjugates (ADCs), CAR-Ts, small molecules, and oncolytic viruses
- Experts in disease relevant in vivo tumor models including syngeneic, CDX, and orthotopic models
- Global infrastructure with 7 preclinical labs and 4 radiochemistry centers

How Can We Help?
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De-risk and Accelerate Your Oncology & RLT Pipeline
Radioligand Therapy & Theranostic Imaging
Support your RLT program with comprehensive imaging and dosimetry services. We design studies using diagnostic/therapeutic isotope pairs (e.g., Zr-89/Lu-177 or Pb-203/Pb-212) to evaluate biodistribution, tumor targeting, and normal tissue dose.
- Surrogate isotope imaging to project human dosimetry
- Alpha and beta emitter experience (Ac-225, Lu-177, Pb-212, At-211)
- Personalized imaging strategies for patient selection and IND submission readiness
Theranostic Agent Development
Design and validate companion imaging agents for patient stratification and dose prediction using isotopes like F-18, Ga-68, Cu-64, and Zr-89.
Cell & Gene Therapy Tracking
Visualize CAR-T, oncolytic virus, and engineered cell biodistribution in real time using bioluminescence and advanced radiolabeling.
Efficacy in In Vivo Tumor Models
Quantify efficacy in disease-relevant models to increase translational confidence and guide candidate selection.
Advanced Image Analysis
Gain fast, actionable insights through automated data processing pipelines—supporting segmentation, dosimetry, PK/PD evaluation, and therapeutic response modeling.
Radiochemistry & Labeling Capabilities
End-to-End Radiolabeling & Chemistry Services for Oncology R&D
- Customized radioligand development to support radiopharmaceutical therapy programs
- Radiolabeling for PET, SPECT, and radiotherapeutic isotopes (F-18, Zr-89, Lu-177, Pb-212, Ac-225, At-211)
- Development and transfer of labeling methods for antibodies, peptides, small molecules, cells, and nucleic acids
- In-house QC, purification, stability testing, and kinetic analysis
- Integrated imaging and post-mortem workflows for full biological insight
Radionuclide Experience:
| Application | Radionuclide |
|---|---|
| PET | 18F 18F (GMP) 64Cu 11C (GMP) 68Ga 89Zr 89Zr (GMP) 124I 86Y 52Mn |
| SPECT half life <24 h | 99mTc 123I 123I (GMP) 99mTc (GMP) |
| SPECT long-lived | 67Ga 75Se 111In 125I 203Pb 67Cu |
| Alpha Therapeutics | 225Ac 211At 212Pb |
| Beta Therapeutics | 177Lu 186Re 188Re 161Tb 90Y 131I 67U |
| Low energy beta emitters | 3H 14C 32P 35S |

Flexible, Scalable Platforms Built for Innovation
Therapeutic Modality
- Radioligand Therapy & Theranostics
- Antibody-Drug Conjugates (ADCs)
- Small Molecules & Peptides
- Cell & Gene Therapies
- External Beam Radiation
Capabilities
- Biodistribution, efficacy, dosimetry
- Labeling, targeting, pharmacokinetics
- Imaging, PK/PD, target validation
- Viral tracking, in vivo distribution
- CT-guided focal beam delivery
Resources
Advancing Radioligand Therapy Development Through Robust Preclinical and Translational Tools
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Precision Theranostics for Triple Negative Breast Cancer Using Transformed MUC1 Targeting
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Advanced Dual-Isotope Imaging Reveals How Antibody-Drug Conjugates Deliver Payloads to Tumors
Read moreReady to Move Your Oncology and Radiopharmaceutical Program Forward?
Let’s design the right imaging strategy to get you there.
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