Calyx and Invicro agree to combine and create a global leader in medical imaging and software solutions for the clinical research community

Calyx, a leading technology-enabled provider of Medical Imaging services and IRT/RTSM (Interactive Response Technology/Randomised Trial Supply Management) to drug developers, and Invicro, a next-generation quantitative imaging biomarker company and pre-eminent development partner to pharma sponsors, have agreed to combine their businesses. This complementary combination will create a new global leader in the provision of medical imaging solutions and development services to the clinical research community.

The enlarged Group (“Group”) formed through this strategic combination will see 100% of Invicro being acquired by Calyx from its current owner, REALM IDx, Inc. The transaction is subject to regulatory filings and customary closing conditions and is expected to complete in Q2 2024.


Cell Stress and Mitochondrial Dysfunction Found in Early Alzheimer’s Disease Patients, Findings Published in Science Translational Medicine

NEEDHAM, Mass. – August 17, 2022 – Invicro LLC (Invicro), a global, industry-leading imaging CRO, and a subsidiary of REALM IDx, Inc., today announced the publication of the paper “Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease1” in Science Translational Medicine.

The study provides novel in vivo evidence for widespread, clinically relevant cellular stress and bioenergetic abnormalities in patients with early-stage Alzheimer’s Disease (AD) and highlights the potential value of mitochondrial imaging in longitudinal studies of AD.


Telix and Invicro Advance AI Partnership

Melbourne (Australia) and Boston, MA (U.S.A.) – June 14, 2022. Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) today announces that it has advanced a partnership with Invicro LLC (Invicro), a global, industry-leading imaging CRO, and part of REALM IDx, Inc., to develop an artificial intelligence (AI) platform to accompany Telix’s PSMA-PET imaging agent, Illuccix® (kit for the preparation of gallium Ga 68 gozetotide) – known as TelixAI™.

TelixAI™ seeks to increase the efficiency and reproducibility of clinicians’ imaging assessments using advanced analysis capabilities with an initial focus on prostate cancer. The platform is designed to do this by automatically separating healthy versus abnormal tracer uptake and then classifies lesions as either visceral (soft tissue) or bone lesions.


ImaginAb announces a new supply agreement with Invicro to offer clinical doses of ImaginAb’s CD8 investigational ImmunoPET imaging agent (zirconium Zr 89 crefmirlimab berdoxam) for Immuno-Oncology (I-O) preclinical research and clinical trials.

Inglewood, Calif., May 12th, 2022– ImaginAb Inc., a market leading global biotechnology company focused on developing next generation ImmunoPET imaging agents and therapeutic radiopharmaceuticals (RPT), today announced an agreement with Invicro LLC, a global, industry-leading imaging CRO, and part of REALM IDx, Inc., to supply clinical doses of ImaginAb’s investigational CD8 ImmunoPET agent (zirconium Zr 89 crefmirlimab berdoxam) for use in clinical trials as part of Invicro’s global core lab imaging service. The agreement also allows Invicro to produce zirconium Zr 89 crefmirlimab for its preclinical offerings.

This offering is a response to the growth seen in I-O therapies and demand from pharmaceutical and biotech companies for advanced, non-invasive, whole-body imaging biomarkers. ImaginAb’s investigational CD8 ImmunoPET agent provides a number of potential benefits that may help inform early decision making through Phase I-IV I-O clinical trials.


Invicro Opens New Global Headquarters and Laboratory in Needham, Massachusetts


NEEDHAM, Mass., May 5, 2022 Invicro LLC, a part of REALM IDx, Inc., today announced the relocation of its global headquarters and expansion of its U.S. laboratories for radiology and pathology imaging services to Needham, Mass., to provide more resources to support pharmaceutical and biotechnology companies and their development of life-changing drugs.

Imaging technologies, such as MRI, CT and PET are a critical and growing part of patient care, including the diagnosis, staging and tracking of disease and treatment. In the development of new medicines, imaging enables a personalized assessment of disease burden and drug response. Invicro’s imaging services and expanded facilities will provide more resources to pharmaceutical and biotechnology companies, offering next-generation biomarkers backed by world-class capabilities that support new drug discoveries for patient care that span from discovery research to global clinical trials.


Invicro, DTi, and NIH Bring Imaging and Genomics Data Together with Advanced Analytics to Help Improve Therapies in Dementia


(BOSTON, MA) September 28, 2021 – Invicro LLC, a REALM IDx, Inc company, announces a collaboration with the National Institutes of Health’s new intramural research effort, the Center for Alzheimer’s and Related Dementias (CARD), through a data science contract with Data Tecnica International LLC (DTi), to offer a curated collection of harmonized brain imaging and genomics data that will help identify dementia and other neurodegenerative disorder risk factors to better stratify subjects and their disease progression.

“We are excited to collaborate with CARD on this significant effort,” stated Dr. Jacob Hesterman, Founding Partner and Chief Technology Officer for Invicro. “This collaboration provides an outstanding opportunity to make the highest quality image analysis available to the broader scientific community and contribute to the mission of Open Science. Together, we form the multi-disciplinary team needed to deliver on the promise of rich, curated multi-omic data offered by large, complex data sets.”


Konica Minolta Precision Medicine Announces Changes to Executive Leadership Team

Aliso Viejo, CA., May 4, 2021 — Konica Minolta Precision Medicine, Inc. (KMPM) announced today changes to its executive leadership team effective immediately. The changes reflect a thoughtful and strategic approach to the next phase of growth and expansion for the global precision diagnostics organization.

Aaron Elliott, current CEO of Ambry Genetics, has been named Chief Executive Officer of KMPM. In his new role, Dr. Elliott will be responsible for driving execution across all KMPM business units, which include Ambry Genetics, Invicro, and KMPM-Japan. During his 13-year tenure at Ambry, Dr. Elliott also served as Chief Operating Officer and Chief Scientific Officer, and saw the company through many trailblazing milestones including numerous novel first to market diagnostic tests, the landmark BRCA gene patent case which opened up genetic testing in the United States and the acquisition by Konica Minolta.


Konica Minolta Precision Medicine Collaborates with AWS to Create the Next Generation of Precision Diagnostics

Tokyo (March 10, 2021)Konica Minolta Precision Medicine, Inc. (KMPM), a Konica Minolta Group company, announced today a five-year collaboration with Amazon Web Services, Inc. (AWS). As the Preferred Cloud Provider for KMPM, AWS will support the build-out of the company’s LATTICETM initiative globally. LATTICETM is a groundbreaking integrated diagnostic data platform that combines genomics, pathology, and radiology data along with other critical information to uncover new, clinically relevant biomarkers and create the next generation of diagnostic tests. As part of this collaboration, Amazon has made a financial investment in KMPM.


TauIQ launches in Invicro’s Core Lab alongside seminal publication in the Journal of Nuclear Medicine


BOSTON, MA, 01 February 2021 Invicro LLC, a Konica Minolta company announces that the paper, TauIQ – A canonical image-based algorithm to quantify tau PET scans, will be published in The Journal of Nuclear Medicine (JNM). In conjunction with this publication, Invicro has launched 21 CFR Part 11 compliant TauIQ services in its Core Lab as part of its expanded IQ-Analytics Platform, which includes AmyloidIQ and DaTIQ.


Konica Minolta Precision Medicine, Inc. Acquires Backpack Health Assets

Aliso Viejo, CA (20 May 2020), Konica Minolta Precision Medicine, Inc. (KMPM), a subsidiary of Konica Minolta, Inc. (Konica Minolta) today announced the acquisition of the assets of Backpack Health (BPH), a secure mobile and web-based health data management platform.