Central Nervous System (CNS)
Overview
Invicro has spent 20 years specializing in neuroscience imaging solutions for preclinical, early phase and late phase clinical studies. Our capabilities span from in vitro assays to in vivo imaging using PET, SPECT and MRI imaging biomarkers in CNS drug development and CNS clinical trials. We have expertise in coordinating worldwide multi-center imaging studies, and providing management and oversight of radiotracer supply for both commercial and non-commercially available agents. Solutions include:
CNS Expertise
Invicro has industry leading operational oversight and extensive experience with preclinical, early phase (single-site) and late phase (multi-center) trials. This enables us to provide sponsors with unparalleled support and guidance to ensure successful study execution.
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- 430+ clinical CNS imaging trials managed
- >200 AD and PD Studies with >56,000 subjects imaged
- 90+ Phase I & II, multi-center trials conducted with PET and MRI
- 2100+ imaging centers qualified worldwide
- Two “in-house” clinical imaging centers
- Development and application of 140+ novel neuro imaging agents
- Redefining imaging analytic techniques
- Amyloid, Tau and Dat IQ analytics
- SUVR analysis
- Centiloid analysis
- 430+ clinical CNS imaging trials managed
Solutions
Preclinical
Invicro has many years of experience supporting preclinical CNS drug discovery and development programs. Our tissue biomarker services along with our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as biodistribution, target-occupancy relationships and therapeutic efficacy.
- Biodistribution
- Target Engagement & Occupancy Studies
- Neuropharmacodynamics
- Neurotransmitter Release
- Biological Therapeutics Pharmacokinetics
- Neuroinflammation
- Neuromodulator Analysis
- Learn More
Early Phase Clinical
We support a wide range of first-in-human, pre-proof of concept CNS clinical trial imaging studies spanning phases I-IIa.
MRI
- Brain volumetric analysis
- Changes in brain activity and cerebral blood flow
- Tissue microstructure
- Tissue susceptibility
- Pharmacodynamic responses
PET
- Radioligand dosimetry
- Quantitative drug brain distribution
- Target engagement
- Drug concentration – Target occupancy relationship
- Pharmacodynamic responses
Late Phase Clinical
Invicro’s Late Phase (IIb-IV) CNS clinical trial imaging capabilities enable the execution and delivery of large-scale clinical trials for diagnosis, progression, and disease monitoring through optimized study design, world-wide imaging site set up, iPACs driven data management and quantitative analytics. This end-to-end service is deployed in the necessary regulatory infrastructure to deliver clinical trial results ready for regulatory filing.
- Core lab capabilities with complete project support
- Clinical imaging center evaluation, selection, set up, training and management
- Rapid analysis for study eligibility
- Quantitative analysis for monitoring drug effect
- Image data management and regulatory compliance services
Advanced Image Analytics
We develop advanced algorithms and pipelines to solve complex image science problems, including the use of machine learning and deep learning techniques. These methods are built on our deep scientific domain knowledge to deliver optimal analytical performance and relevant biological outcome measures for a variety of tasks, including:
- IQ Analytics Suite – Tau, Amyloid and DaT Imaging
- Batch Image Triage & QC
- Tracer Kinetic Analysis
- Biomathematical Modeling
- Image Registration, Segmentation and Volumetric Analysis
- Radiation Dosimetry
Thought Leadership Content
Case Studies
Webinars
Molecular Imaging in Neurodegenerative Disorders: Developing a Translational Toolbox
Wherefore art Tau? Developing Methods for the Qualitative Interpretation of Tau PET
The IQ Analytics Platform: Amyloid-IQ, Tau-IQ and Dat-IQ
What Can we Learn from Primary Age-Related Tauopathy (PART)
Chemistry External Manufacturing and Network Management
Development of Novel PET Radioligands for PET Imaging Applications
Molecular and functional imaging in early phase drug development
Imaging biomarkers for measuring pharmacodynamic effects of CNS drugs