Invicro has spent 20 years specializing in neuroscience imaging solutions for preclinical, early phase and late phase clinical studies. Our capabilities span from in vitro assays to in vivo imaging using PET, SPECT and MRI imaging biomarkers in CNS drug development and CNS clinical trials. We have expertise in coordinating worldwide multi-center imaging studies, and providing management and oversight of radiotracer supply for both commercial and non-commercially available agents. Solutions include:


  • Histopathology
  • Preclinical Imaging
  • Phase 0-IV Imaging Support
  • Clinical Imaging Core Lab
  • Advanced Image Analytics Including Novel IQ Analytics Suite
  • Quantitative Imaging Endpoints

CNS Expertise

Invicro has industry leading operational oversight and extensive experience with preclinical, early phase (single-site) and late phase (multi-center) trials. This enables us to provide sponsors with unparalleled support and guidance to ensure successful study execution.

    • 370+ clinical imaging trials managed
      • >200 AD and PD Studies with >56,000 subjects imaged
    • 90+ Phase I & II, multi-center trials conducted with PET and MRI
    • 2100+ imaging centers qualified worldwide
    • Two “in-house”clinical imaging centers
    • Development and application of 90+ novel neuro imaging agents
    • Redefining imaging analytic techniques
      • Amyloid, Tau and Dat IQ analytics
      • SUVR analysis
      • Centiloid analysis



Invicro has many years of experience supporting preclinical CNS drug discovery and development programs. Our tissue biomarker services along with our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as biodistribution, target-occupancy relationships and therapeutic efficacy.

  • Tissue Biomarker Development 
  • Biodistribution
  • Target Engagement & Occupancy Studies
  • Neuropharmacodynamics
  • Neurotransmitter Release
  • Biological Therapeutics Pharmacokinetics
  • Neuroinflammation
  • Neuromodulator Analysis
  • Neurogenetics

Learn More

Early Phase Clinical

We support a wide range of first-in-human, pre-proof of concept CNS clinical trial imaging studies spanning phases I-IIa.



  • Brain volumetric analysis
  • Changes in brain activity and cerebral blood flow
  • Tissue microstructure
  • Tissue susceptibility
  • Pharmacodynamic responses



  • Radioligand dosimetry
  • Quantitative drug brain distribution
  • Target engagement
  • Drug concentration – Target occupancy relationship
  • Pharmacodynamic responses

Learn More

Late Phase Clinical

Invicro’s Late Phase (IIb-IV) CNS clinical trial imaging capabilities and tissue biomarker services enable the execution and delivery of large-scale clinical trials for diagnosis, progression, and disease monitoring through optimized study design, world-wide imaging site set up, iPACs driven data management and quantitative analytics. This end-to-end service is deployed in the necessary regulatory infrastructure to deliver clinical trial results ready for regulatory filing.

  • Tissue biomarker testing and development 
  • Core lab capabilities with complete project support
  • Clinical imaging center evaluation, selection, set up, training and management
  • Rapid analysis for study eligibility
  • Quantitative analysis for monitoring drug effect
  • Image data management and regulatory compliance services

Learn More

Advanced Image Analytics

We develop advanced algorithms and pipelines to solve complex image science problems, including the use of machine learning and deep learning techniques. These methods are built on our deep scientific domain knowledge to deliver optimal analytical performance and relevant biological outcome measures for a variety of tasks, including:

  • IQ Analytics Suite – Tau, Amyloid and DaT Imaging
  • Batch Image Triage & QC
  • Tracer Kinetic Analysis
  • Tissue Biomarker Analysis 
  • Biomathematical Modeling
  • Image Registration, Segmentation and Volumetric Analysis
  • Radiation Dosimetry

Learn More

Invicro's CNS Leaders

Ilan Rabiner, M.D. | EVP, Head of Translational Applications

Dr. Rabiner is a psychiatrist and psycho-pharmacologist who was part of the team that set up the GlaxoSmithKline Clinical Imaging Centre, which transitioned to become Imanova and later acquired by Invicro.

Kenneth Marek, M.D. | Distinguished Scientist

Dr. Marek is an Internationally recognized expert in imaging of neurodegenerative disorders and has made significant contributions to early detection and diagnostic use of radiotracers for AD, PD, HD and other disorders.

John Seibyl, M.D. | Distinguished Scientist

Dr. Seibyl is an international expert on PET and SPECT neuroimaging and he has made significant contributions to the development of visual and quantitative analysis for imaging in neurodegenerative and neuropsychiatric disorders.


  • Core histology
  • Multiplex Immunohistochemistry (IHC)
  • Multiplex Immunofluorescence (IF)
  • Quanticell™ high sensitivity immunohistochemistry (IHC)
  • RNAScope® ISH
  • BaseScope™ ISH
  • miRNAScope™ ISH
  • PET
  • MRI
  • CT
  • Additional novel modalities include: Resting state fMRI, phMRI, MRS, DCE-MRI, ALS and Dynamic X-Ray